Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study
نویسندگان
چکیده
OBJECTIVE In this pilot study, the effect of sildenafil on digital ulcer (DU) healing and related clinical symptoms was analysed. METHODS A total of 19 patients with systemic sclerosis (SSc) were treated with maximally tolerated sildenafil doses up to 6 months. Primary outcome was the healing of DUs. Changes in other clinical symptoms were also evaluated. RESULTS In all, 49 DUs were present at baseline; this decreased to 17 ulcers (p<0.001) at the end of sildenafil treatment. Furthermore, the visual analogue scale (VAS) score for Raynaud's phenomenon (RP), pain and activity improved (p=0.003, p=0.002 and p=0.05, respectively). A total of 9 patients developed 12 new DUs during sildenafil treatment. CONCLUSIONS This study indicates an effect of sildenafil on DU healing in patients with SSc and an improvement of RP and associated symptoms that should be validated in controlled studies.
منابع مشابه
Oral sildenafil for the treatment of Raynaud's phenomenon and digital ulcers secondary to systemic sclerosis.
R aynaud’s phenomenon (RP) with or without digital ulcer formation is a significant cause of morbidity for patients with systemic sclerosis (SSc, scleroderma). Lichtenstein reported oral sildenafil as a treatment of RP for patients with SSc, systemic lupus erythematosus, and idiopathic RP. His report included 10 patients from his community office practice given sildenafil, 50 mg once orally at ...
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In systemic sclerosis, the collagen deposition, vasculopathy, and Raynaud phenomenon produce abnormalities in microcirculation that lead to ischemia, distal ulceration (DU) and, occasionally, necrosis of one or more phalanges.1 We report 2 cases in which sildenafil was used as a treatment option. The first case was a 46-year-old woman with a history of diffuse cutaneous systemic sclerosis diagn...
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